About the Book:

·         Clarke’s Analysis of Drug and Poisons is the definitive source of analytical data for drugs and poisons. This reference work has been completely revised and updated for the new edition and comprises two volumes.

Volume 1 has been greatly expanded from 31 to 44 chapters providing extensive coverage of all methodology and analytical techniques. Of significant interest include:

1.    Quality control and assessment - separated into two chapters to reflect the differing situations/purposes/remits of the toxicology laboratory versus the pharmaceutical industry (accreditation with ISO17025 becoming the international standard in labs)

2.    Method development and validation - now present since reliable analytical techniques and data should be of the utmost importance to any analyst

3.    'Sampling, storage and stability', 'Measuring and reporting uncertainty' and 'Interpretation of results' now included to cover all aspects accreditation

4.    Pharmacokinetics now coupled with Pharmacogenomics

Volume 2 now contains:

1.    Over 2100 monographs detailing physical properties, analytical methods, pharmacokinetic data, ultraviolet, infrared and mass spectra, and therapeutic and toxicity data of drugs and poisons

2.    More than 350 new monographs

3.    Expanded indexes and appendices include CAS numbers, empirical and molecular formulae, TLC, GC and HPLC systems data, as well as therapeutic class.

Contents: 

Volume – I:

Part-I: Chapters

1.    Hospital Toxicology,

2.    Therapeutic Drug Monitoring

3.    Workplace Drug Testing

4.    Driving Under the Influence of Alcohol

5.    Driving Under the Influence of Drugs

6.    Drug Testing in Human Sport

7.    Drug Testing in Animal Sport

8.    Drug-facilitated Sexual Assault

9.    Forensic Toxicology

10. Postmortem Toxicology

11. Drugs of Abuse

12. Medicinal Products

13. Solid Dosage Form Identification

14. Volatile Substances

15. Natural Toxins

16. Pesticides

17. Metals and Anions

18. Drugs in Saliva

19. Hair Analysis

20. Method Development and Validation

21. Quality Control in the Pharmaceutical Industry

22. Quality Control and Accreditation in the Toxicology

23. Measuring and Reporting Uncertainty

24. Pharmacokinetics and Metabolism

25. Pharmacogenomics

26. Interpretation of Toxicology Data

27. Paediatric Toxicology

28. Sampling, Storage and Stability

29. Extraction

30. Colour Tests

31. Immunoassays

32. Ultraviolet, Visible and Fluorescene Spectrophotometry

33. Infrared Spectroscopy

34. Near-infrared Spectroscopy

35. Raman Spectroscopy

36. Nuclear Magnetic Resonance Spectroscopy

37. Mass Spectrometry

38. Liquid Chromatography-Mass Spectrometry

39. Thin Layer Chromatography

40. Gas Chromatography

41. High Performance Liquid Chromatography

42. Capillary Electrophoresis

43. Atomic Absorption Spectroscopy, Inductively Coupled Plasma-Mass Spectrometry and other Techniques for measuring the Concentrations of Metals

44. Emerging Techniques

Volume – II

Part-III: Monographs

About the Editors:

Professor Anthony C. Moffat is Emeritus Professor of pharmaceutical Analysis at The School of Pharmacy, University of London, where he was previously Head of the Centre for pharmaceutical Analysis. He was also Chief Scientist at the Royal Pharmaceutical Society. He has over 350 publications as well as the co-authorship of eight books.

Previously he worked for the Forensic Science Service for 23 years as Research Co-ordinator (Birmingham Laboratory), Resources Manager (Huntingdon Laboratory), Head of Quality Management (HQ, London), Assistant Director (Huntingdon Laboratory), and Head of the Drugs and Toxicology Division at the Home Office Central Research Establishment, Aldermaston. He has also been a Superintendent Pharmacist in a community pharmacy, Assistant Professor of Biochemistry, Baylor College of Medicine, Houston, Texas, and Chief Pharmacists, St. Leonard’s Hospital, London.

An active member of many professional and learned societies, his fellowship include the Royal Pharmaceutical Society, Royal Society of Chemistry, Forensic Science Society, International, Pharmaceutical Federation and the American Association of Pharmaceutical Scientists as well as the membership of the International Association of Forensic Toxicologists.

Professor M. David Osselton started his forensic toxicology career in 1974 when he went to work with Dr. Alan Curry at the Home Office Central Research Establishment, Aldermaston. He gained casework experience as Senior Toxicologist working at the Home Office Forensic Science laboratories in Nottingham and huntingdon before returning to Aldermaston in 1984 to succeed Dr. Anthony Moffat as Head of Research in Alcohol, Drugs and Toxicology. In 1991, he was appointed Head of Toxicology for the Forensic Science Service. In 2007 Professor Osselton went to Bournemouth University as Head of the Centre for Forensic Sciences. He has wide experience in toxicology casework and has been involved in numerous high profile cases working for the defence and prosecution both in the UK and overseas. He is internationally known for his research interests in toxicology and lectures widely at conferences as a plenary and keynote speaker. Between 2003 and 2009 he was Lead Assessor (Toxicology) for the UK Council for the Registration of Forensic Practitioners (CRFP) and was Visiting Professor to the Department of Forensic Science and Drug Monitoring at Kings College, University of London (2004-2007). He is a fellow/Member of a number of professional and learned bodies including the Royal Society of Chemistry, Royal Society of Medicine, Expert Witness Institute, International Association of Forensic Toxicologists (TIAFT), Society of Forensic Toxicologists (SOFT), LTG (formally the London Toxicology Group), UK Workplace Drug testing Forum and is chair of the United Kingdom and Ireland Association of Forensic Toxicologists.   

Dr. Brian Widdop was Director of the Medical Toxicology Unit Laboratory at Guy’s Hospital, London, from 1970 until 2002. Dr. Widdop has been a Speciality Assessor for the Council for the Registration of Forensic Practitioners, a member of the WHO IPCS Working Group on Analytical Toxicology, Chief Advisor to the South East Asia Regional Office of the WHO on analytical toxicology and was a Director of the Board of the UK Horse–racing Forensic Laboratory from 1991 to 2002. From 1997 to 2001, he was joint co-ordinator of the European proficiency Testing Scheme for Drugs of Abuse. Dr. Widdop has published over 80 papers on various aspects of clinical and analytical toxicology and has spoken at many international meetings. He is also a member of the editorial board of the journal of Analytical Toxicology.

Dr. Widdop belongs to several international scientific societies and was a founder of the London Toxicology Group. He has been a member of the International Association of Forensic Toxicologists for 42 years and was the recipient of the Alan Curry Award in 2002.