Contents

Part A. General Molecular Principles of Drug Design : 1. Basic Principles of Drug Design I - Drug Molecules: Structure and Properties 2. Basic Principles of Drug Design II: Receptors: Structures and Properties 3. Basic Principles of Drug Design III: Designing Drug Molecules to Fit Receptors: Part B. Biochemical Considerations in Drug Design: 4. Messenger Targets for Drug Action I: Neurotransmitters and Their Receptors 5. Messenger Targets for Drug Action II: Hormones and Their Receptors 6. Messenger Targets for Drug Action III: Immuno modulators and Their Receptors 7. Non messenger Targets for Drug Action I: Endogenous Cellular Structures 8. Non messenger Targets for Drug Action II: Endogenous Macromolecules 9. Non messenger Targets for Drug Action III: Exogenous “Nonself” Pathogens Appendix A: Drugs Arranged by Pharmacologic Activity