About the Book:

First published in 1976, this handbook is known for being a user-friendly consolidation of pharmacokinetic principles and techniques for practitioners, researchers, and students that merits a place in any personal or college library. In this seventh edition, 10 chapters have been substantially revised to address recent developments and incorporate new information, illustrations, and equations and up-to-date literature citations. The appendix has been expanded to include parameters for some 150 additional drugs.

“An excellent reference for practioners with formal training in pharmacokinetics as well as undergraduate and graduate students who are being exposed to pharmacokinetics for the first time.” 

-From review of 6^th edition by Thomas Jacobsen, PharmD, MS Doody’s Review Service

Key Features:

·         Chapters on the following topics have been updated: Absorption/Transport Mechanisms, Physicochemical and Biological Factors Affecting in vivo performance of Drugs, Drug Biotransformation, Excretion and Clearance of Drugs, Pediatric Pharmacokinetics, First-Dose Size in Man, Correlation of Clinical Response with Drug Disposition, Bioavailability and Bioequivalence, Extracorporeal Methods of Drug Removal, and Pharmacogenetics and Pharmacogenomics.

·         More than 100 pharmacokinetic terms are defined in Chapter1.

·         Pharmacokinetic data complied from the literature on nearly 800 drugs— 150 new to this edition—are presented in the tabular appendix.

Contents:

1.    Definitions and Nomenclature

2.    The LADMER System: Liberation, Absorption, Distribution, Metabolism, Elimination, and Response

3.    Organs, Tissues, Cells, and Organelles

4.    Cell Membranes

5.    Drug–Receptor Interactions

6.    Absorption/Transport Mechanisms

7.    pKa and Degree of Ionization

8.    Lipid/Water Partition Coefficient

9.    Physicochemical and Biological Factors Affecting In Vivo Performance of Drugs

10. Biopharmaceutical Data on the Gastrointestinal Tract

11. Fluid Compartments and Circulatory System

12. Binding of Drugs to Biological Material

13. Drug Biotransformation

14. Compartment Models

15. Determination of Rate Constants

16. Volume of Distribution and Distribution Coefficient

17. Excretion and Clearance of Drugs

18. Urinary and Biliary Recycling

19. Cumulative Urinary Excretion

20. Area Under the Blood Level–Time Curve

21. Pharmacokinetics of Single-Dose Administration

22. Pharmacokinetics of Multiple Dosing

23. Compartment-Model-Independent Analysis

24. Pediatric Pharmacokinetics

25. Drug Dosage in Elderly Patients

26. Drug Dosage in Obese Patients

27. Drug Disposition in Pregnancy

28. Dosage Regimen Design

29. Drug Monitoring and Dose Adjustment

30. Physiologic and Pathologic Factors Influencing Drug Response

31. First-Dose Size in Man

32. Forensic Pharmacokinetics

33. Nonlinear Pharmacokinetics

34. Curve Fitting

35. Correlation of Clinical Response with Drug Disposition

36. Bioavailability and Bioequivalence

37. Body Surface Areas

38. Extracorporeal Methods of Drug Removal

39. Pharmacogenetics and Pharmacogenomics

About the Authors:

Wolfgang A. Ritschel is one of the world’s foremast experts in the discipline of Pharmacokinetics. The author or coauthor of 13 books and more than 450 articles on pharmacokinetics, biopharmaceutics, technology, and pharmacology, he is Professor Emeritus of Pharmacokinetics and Biopharmaceutics, University of Cincinnati College of Pharmacy and Professor Emeritus of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine.