About the Book:

Following the developments of LC-MS in the last decade and its establishment as the method of choice in the pharmaceutical industry, the technique is increasingly being used in other scientific disciplines, including analytical toxicology.

Applications of LC-MS in Toxicology covers all essential theoretical aspects of LC-MS, comprising: technical details of the instrumentation and different operating modes, method development, optimisation and validation, quantification, criteria for identification and confirmation. Further chapters cover in detail the application of LC-MS in areas such as: systematic toxicological analysis, drugs of abuse, therapeutic drug monitoring, doping in sport, pesticides, peptides, and further forensic applications.

This authoritative text is essential reading for all forensic and clinical toxicologists and will also be relevant to pharmaceutical analysts as well as analytical chemists.

Contents:

1.    Ionisation, Ion Separation and Ion Detection in LC-MS

2.    Method Development and Optimisation of LC-MS

3.    Quantification Using LC-MS

4.    Method Validation Using LC-MS

5.    Identification and Confirmation Criteria for LC-MS

6.    Systematic Toxicological Analysis with LC-MS

7.    Analysis of Therapeutic Drugs with LC-MS

8.    LC-MS of Drugs of Abuse and Related Compounds

9.    LC-MS in Doping Control

10. Pesticide Analysis Using LC-MS

11. Pepticide Analysis Using LC-MS

12. LC-MS in forensic chemistry

About the Author:

Aldo polettini graduated in Biological Sciences at the University of Milan (1980-1985) and obtained his PhD in Forensic Toxicology at the University of Pavia (1987-1993). He worked as a Post-doctoral Researcher in many organizations including: the Joint Research Centre of the European Union, Ispra, Italy (1986), the Municipal Institute for Medical Research, Barcelona, Spain (1992) during the Olympic Games, the National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands (1994), and the National Institute on Drug Abuse, Baltimore, MD, USA (2000). He is currently Associate Professor of Forensic Toxicology and responsible for the Laboratory of Analytical Toxicology of the Department of Legal Medicine and Public Health of the University of Pavia.

He is author of over 60 peer-reviewed papers, a member of the Editorial Board of the Journal of Analytical Toxicology and a member of the Systematic Toxicological Analysis (STA) and Guidelines Committee of The International Association of Forensic Toxicologists (TIAFT).

His main research interests are the development of new analytical methods for trace organic compounds in biosamples using hyphenated chromatographic and mass spectroscometric techniques, STA by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC)-MS, doing control, and drugs of abuse in hair.