About the Book:
With this book as
their guide, readers have access to all the current information needed to
thoroughly investigate and accurately determine a compound's pharmaceutical
properties and their effects on drug absorption. The book emphasizes oral
absorption, explaining all the physicochemical methods used today to analyze
drug candidates. Moreover, the author provides expert guidance to help readers
analyze the results of their studies in order to select the most promising drug
candidates.
This Second Edition has been
thoroughly updated and revised, incorporating all the latest research findings,
methods, and resources, including:
· Descriptions
and applications of new PAMPA models, drawing on more than thirty papers
published by the author's research group
· Two
new chapters examining permeability and Caco-2/MDCK and permeability and the
blood-brain barrier
· Expanded
information and methods to support pKa determination
· New
examples explaining the treatment of practically insoluble test compounds
· Additional
case studies demonstrating the use of the latest physicochemical techniques
· New,
revised, and expanded database tables throughout the book
Well over 200 drawings help readers
better understand difficult concepts and provide a visual guide to complex
procedures. In addition, over 800 references serve as a gateway to the primary
literature in the field, facilitating further research into all the topics
covered in the book.
This Second Edition is recommended
as a reference for researchers in pharmaceutical R&D as well as in
agrochemical, environmental, and other related areas of research. It is also
recommended as a supplemental text for graduate courses in pharmaceutics. |
