About the book:
This comprehensive reference/text demonstrate the
relationship of the basic theory of solid extraction (SPE) to
chromatography-illustrating how SPE techniques significantly contribute to the
preparation of samples for a wide variety of analytical techniques, including
gas chromatography, mass spectrometry, and high-performance liquid
chromatographic analyses.
Providing step-by-step details on the applications
of SPE to environmental matrices, broad-spectrum drug screening, veterinary
drug abuse, pharmaceutical drug development biological samples, and
high-throughput screening and written by world renowned experts in the field,
Solid-Phase Extraction thoroughly covers digital chromatography, the basic
elements of SPE, capacity and selectivity, and the mechanism of adsorption and
desorption… nonpolar, polar and ion-exchange extraction mechanisms, as well as
complexation, chelation, and covalent retention … actual vs. ideal performance
and predictive SPE, as well as expert systems … using and eliminating secondary
interactions and mixed-mode SPE … preparing and handling biological fluids
particulates, solid and air samples by SPE … creating affinity sorbents and the
properties and uses of affinity SPE … automation approaches, techniques for
automated method development, off-line solid extraction, and on-line SPE …
complementary use of SPE and supercritical fluid extraction … and more.
Containing helpful reference charts, tables of
solvent properties, selectivities, molecular acid/base properties, and more,
Solid-Phase Extraction is an essential, on-the-job reference for analytical,
environmental, synthetic organic, and medicinal chemists and biochemists, and
toxicologists; and an ideal textbook for upper-level undergraduate, graduate,
and continuing-education courses in sample separation or preparation, including
quantitative analysis, separation science, analytical chemistry, biochemical
analysis, and organic synthesis and purification. |
Contents:
1. Introduction to Solid-Phase Extraction 2. SPE Sorbents and Formats 3. The Sample Matrix and Its Influence on Method Development 4. Handling Large Volume Samples: Applications of SPE to
Environmental Matrices 5. SPE Technology - Principles and Practical Consequences 6. Theory Meets Practice 7. Secondary Interactions and Mixed-mode Extraction 8. Solid-Phase Extraction for Broad-Spectrum Drug Screening in
Toxicological Analysis 9. The Application of SPE to Veterinary Drug Abuse 10. Solid Phase Extraction of Biological Samples 11. Solid Phase Extraction Mediated by Covalent Bonding:
Applications of Immobilized Phenylboronic Acid 12. Immuno-Affinity Extraction 13. Matrix Solid Phase Dispersion (MSPD) 14. Automation of Solid Phase Extraction 15. Integration of SPE with the Analytical Technique, Part I -
Liquid Chromatography 16.
Integration of SPE with
the Analytical Technique, Part II
Concluding
Thoughts - New Directions for SPE |
About the Editor:
Nigel J. K. Simpson is the technical services Manager with Varian, Inc., Harbor city,
California, where he supervises technical support as well as research and
development and product marketing, and develops and field tests SPE products
and their introduction to the marketplace. The author, coauthor, and presenter
of over 200 technical papers and seminars on SPE technology, he is a member of
the American Chemical Society. Dr. Simpson received the B. A. degree (1986) in
general chemistry and the D.phil. degree (1990) in physical chemistry from
Oxford University, England. |
(www.ulektz.com) 
