About the book:

This comprehensive reference/text demonstrate the relationship of the basic theory of solid extraction (SPE) to chromatography-illustrating how SPE techniques significantly contribute to the preparation of samples for a wide variety of analytical techniques, including gas chromatography, mass spectrometry, and high-performance liquid chromatographic analyses.

Providing step-by-step details on the applications of SPE to environmental matrices, broad-spectrum drug screening, veterinary drug abuse, pharmaceutical drug development biological samples, and high-throughput screening and written by world renowned experts in the field, Solid-Phase Extraction thoroughly covers digital chromatography, the basic elements of SPE, capacity and selectivity, and the mechanism of adsorption and desorption… nonpolar, polar and ion-exchange extraction mechanisms, as well as complexation, chelation, and covalent retention … actual vs. ideal performance and predictive SPE, as well as expert systems … using and eliminating secondary interactions and mixed-mode SPE … preparing and handling biological fluids particulates, solid and air samples by SPE … creating affinity sorbents and the properties and uses of affinity SPE … automation approaches, techniques for automated method development, off-line solid extraction, and on-line SPE … complementary use of SPE and supercritical fluid extraction … and more.

Contents:

1.      Introduction to Solid-Phase Extraction

2.      SPE Sorbents and Formats

3.      The Sample Matrix and Its Influence on Method Development

4.      Handling Large Volume Samples: Applications of SPE to Environmental Matrices

5.      SPE Technology - Principles and Practical Consequences

6.      Theory Meets Practice

7.      Secondary Interactions and Mixed-mode Extraction

8.      Solid-Phase Extraction for Broad-Spectrum Drug Screening in Toxicological Analysis

9.      The Application of SPE to Veterinary Drug Abuse

10.   Solid Phase Extraction of Biological Samples

11.   Solid Phase Extraction Mediated by Covalent Bonding: Applications of Immobilized Phenylboronic Acid

12.   Immuno-Affinity Extraction

13.   Matrix Solid Phase Dispersion (MSPD)

14.   Automation of Solid Phase Extraction

15.   Integration of SPE with the Analytical Technique, Part I - Liquid Chromatography

16.   Integration of SPE with the Analytical Technique, Part II

About the Editor: